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Article

Development of new IL28B genotyping method using Invader Plus assay.

Microbiology and immunology - 1 May 2012

Kani Satomi, Tanaka Yasuhito, Matsuura Kentaro, Watanabe Tsunamasa, Yatsuhashi Hiroshi, Orito Etsuro, Inose Ken, Motojuku Nao, Wakimoto Yukio, Mizokami Masashi

Abstract excerpt

IL28B polymorphism is associated with the response to pegylated interferon-α with ribavirin (PEG-IFN-α/RBV) treatment in chronic hepatitis C patients. As a genotyping assay for IL28B single nucleotide polymorphisms (SNPs) in clinical practice, the Invader Plus assay was developed. The accuracy, intra-assay, inter-assay precision, and the limit of detection of the Invader Plus assay were evaluated. Two SNPs...

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Identifiers

PMID: 22537149
DOI: 10.1111/j.1348-0421.2012.00439.x

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