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Article

Impact of HCV core gene quasispecies on hepatocellular carcinoma risk among HALT-C trial patients.

Scientific reports - 1 Jun 2016

El-Shamy Ahmed, Pendleton Matthew, Eng Francis J, Doyle Erin H, Bashir Ali, Branch Andrea D

Abstract excerpt

Mutations at positions 70 and/or 91 in the core protein of genotype-1b, hepatitis C virus (HCV) are associated with hepatocellular carcinoma (HCC) risk in Asian patients. To evaluate this in a US population, the relationship between the percentage of 70 and/or 91 mutant HCV quasispecies in baseline serum samples of chronic HCV patients from the HALT-C trial and the incidence of HCC was determined by deep...

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Share to Carcinoma, Hepatocellular
Share to Hepacivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Liver Neoplasms

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Share to RNA, Viral

Share to Viral Core Proteins

Source

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Identifiers

PMID: 27246310
DOI: 10.1038/srep27025
PMCID: PMC4887904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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