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Article

Protein aggregation caused by aminoglycoside action is prevented by a hydrogen peroxide scavenger.

Molecular cell - 14 Dec 2012

Ling Jiqiang, Cho Chris, Guo Li-Tao, Aerni Hans R, Rinehart Jesse, Söll Dieter

Abstract excerpt

Protein mistranslation causes growth arrest in bacteria, mitochondrial dysfunction in yeast, and neurodegeneration in mammals. It remains poorly understood how mistranslated proteins cause such cellular defects. Here we demonstrate that streptomycin, a bactericidal aminoglycoside that increases ribosomal mistranslation, induces transient protein aggregation in wild-type Escherichia coli. We further determined the...

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Identifiers

PMID: 23122414
DOI: 10.1016/j.molcel.2012.10.001
PMCID: PMC3525788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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