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Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis

27 Apr 2022

Abstract excerpt

Neurodegenerative protein conformational diseases are characterized by the misfolding and aggregation of metastable proteins encoded within the host genome. The host is also home to thousands of proteins encoded within exogenous genomes harbored by bacteria, fungi, and viruses. Yet, their contributions to host protein-folding homeostasis, or proteostasis, remain elusive. Recent studies, including our previous...

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PMID: 35563197
DOI: 10.3390/ijms23094807

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