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Article

Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway.

The Journal of biological chemistry - 1 Jan 2000

Kritsiligkou Paraskevi, Nowicki-Osuch Karol, Carter Zorana, Kershaw Chris J, Creamer Declan R, Weids Alan J, Grant Chris M

Abstract excerpt

Protein aggregation is the abnormal association of misfolded proteins into larger, often insoluble structures that can be toxic during aging and in protein aggregation-associated diseases. Previous research has established a role for the cytosolic Tsa1 peroxiredoxin in responding to protein misfolding stress. Tsa1 is also known to downregulate the cAMP/protein kinase A (PKA) pathway as part of the response to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33894203
DOI: 10.1016/j.jbc.2021.100690
PMCID: PMC8164027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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