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Article

Chimeric tRNAs as tools to induce proteome damage and identify components of stress responses.

Nucleic acids research - 1 Mar 2010

Geslain Renaud, Cubells Laia, Bori-Sanz Teresa, Alvarez-Medina Roberto, Rossell David, Martí Elisa, Ribas de Pouplana Lluís

Abstract excerpt

Misfolded proteins are caused by genomic mutations, aberrant splicing events, translation errors or environmental factors. The accumulation of misfolded proteins is a phenomenon connected to several human disorders, and is managed by stress responses specific to the cellular compartments being affected. In wild-type cells these mechanisms of stress response can be experimentally induced by expressing recombinant...

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Identifiers

PMID: 20007146
DOI: 10.1093/nar/gkp1083
PMCID: PMC2836549

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