Article
Mutations in the D-loop region and increased copy number of mitochondrial DNA in human laryngeal squamous cell carcinoma.
Molecular biology reports - 1 Jan 2013
Guo Wei, Yang Denghua, Xu Hongbo, Zhang Yang, Huang Junwei, Yang Zheng, Chen Xiaohong, Huang Zhigang
Abstract excerpt
The effects of D-loop mutations and the mtDNA copy number alterations in LSCC are poorly understood. Herein, we investigated the features and roles of somatic mutations of the D-loop region and copy number alterations in mtDNA of LSCC. Using direct sequencing and real-time quantitative PCR, we examined D-loop mutations and mtDNA copy number in LSCC tissues, paracancerous normal tissues and peripheral vein blood...
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