Article
Study on the mutations in the D-loop region of mitochondrial DNA in cervical carcinoma.
Journal of cancer research and clinical oncology - 1 Feb 2009
Chen Daozhen, Zhan Huiying
Abstract excerpt
BACKGROUND: Study on genesis and development of tumor is mainly concentrated on gene mutation in nucleus. But in recent years, the role of mitochondrial DNA (mtDNA) mutation in tumor genesis has been given more attention, which is the only extra-nucleus DNA in cells of higher animals. Carcinoma of the uterine cervix is a common tumor in gynecology. There are few reports of mtDNA mutation in this area. The focus...
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