Article
The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas.
The Journal of thoracic and cardiovascular surgery - 1 Jan 2010
Lin Chen-Sung, Chang Shi-Chuan, Wang Liang-Shun, Chou Teh-Ying, Hsu Wen-Hu, Wu Yu-Chung, Wei Yau-Huei
Abstract excerpt
OBJECTIVE: The study objective was to evaluate the roles of mitochondrial DNA alterations in esophageal squamous cell carcinoma, with emphasis on the changes in the copy number and D310 variants of mitochondrial DNA. METHODS: Paired samples microdissected from esophageal muscles, noncancerous esophageal mucosa, cancerous esophageal squamous cell carcinoma nests, and metastatic lymph nodes of 72 patients with...
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