Article
Gene mutations in the D-loop region of mitochondrial DNA in oral squamous cell carcinoma.
Molecular medicine reports - 1 Jun 2015
Yuan Rong-Tao, Sun Yang, Bu Ling-Xue, Jia Mu-Yun
Abstract excerpt
The present study aimed to investigate gene mutations in the displacement‑loop (D‑loop) region of mitochondrial DNA (mtDNA) in patients with oral squamous cell carcinoma (OSCC) in order to examine the role of gene mutation in mtDNA in OSCC tumorigenesis. mtDNA was obtained from cancer tissues, paracancerous tissues and normal mucosal tissues of thirty patients with OSCC. The D‑loop region of the mtDNA was...
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