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D-loop somatic mutations and ∼5 kb "common" deletion in mitochondrial DNA: important molecular markers to distinguish oral precancer and cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Apr 2015

Datta Sayantan, Chattopadhyay Esita, Ray Jay Gopal, Majumder Mousumi, Roy Puspita Das, Roy Bidyut

Abstract excerpt

Apart from genomic DNA, mutations at mitochondrial DNA (mtDNA) have been hypothesized to play vital roles in cancer development. In this study, ∼5 kb deletion and D-loop mutations in mtDNA and alteration in mtDNA content were investigated in buccal smears from 104 healthy controls and 74 leukoplakia and 117 cancer tissue samples using Taqman-based quantitative assay and re-sequencing. The ∼5 kb deletion in mtDNA...

Topics

Adult
Aged
Biomarkers, Tumor
DNA, Mitochondrial
DNA, Neoplasm
Female
Humans
Leukoplakia, Oral
Male
Middle Aged
Mouth Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Reactive Oxygen Species

Sequence Deletion

Source

Identifiers

PMID: 25527154
DOI: 10.1007/s13277-014-2937-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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