Article
Mitochondrial genome instability and mtDNA depletion in human cancers.
Annals of the New York Academy of Sciences - 1 May 2005
Lee Hsin-Chen, Yin Pen-Hui, Lin Jin-Ching, Wu Cheng-Chung, Chen Chih-Yi, Wu Chew-Wun, Chi Chin-Wen, Tam Tseng-Nip, Wei Yau-Huei
Abstract excerpt
An increase in the rate of glycolysis is one of the metabolic alterations in most cancer cells. However, the role of alterations in mitochondrial function and mitochondrial DNA (mtDNA) in carcinogenesis still remains unclear. In this study, we analyzed the nucleotide sequence of the D-loop and the copy number of mtDNA in 54 hepatocellular carcinomas (HCCs), 31 gastric, 31 lung, and 25 colorectal cancers as well...
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