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Article

Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis.

PloS one - 11 Feb 2011

Ribeiro Diogo, Ellwanger Kristina, Glagow Désirée, Theofilopoulos Spyridon, Corsini Nina S, Martin-Villalba Ana, Niehrs Christof, Arenas Ernest

Abstract excerpt

Dickkopf1 (Dkk1) is a Wnt/β-catenin inhibitor that participates in many processes during embryonic development. One of its roles during embryogenesis is to induce head formation, since Dkk1-null mice lack head structures anterior to midbrain. The Wnt/β-catenin pathway is also known to regulate different aspects of ventral midbrain (VM) dopaminergic (DA) neuron development and, in vitro, Dkk1-mediated inhibition...

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Identifiers

PMID: 21347250
DOI: 10.1371/journal.pone.0015786
PMCID: PMC3037958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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