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Article

Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration.

International journal of molecular sciences - 3 Jun 2020

Volpicelli Floriana, Perrone-Capano Carla, Bellenchi Gian Carlo, Colucci-D'Amato Luca, di Porzio Umberto

Abstract excerpt

The relatively few dopaminergic neurons in the mammalian brain are mostly located in the midbrain and regulate many important neural functions, including motor integration, cognition, emotive behaviors and reward. Therefore, alteration of their function or degeneration leads to severe neurological and neuropsychiatric diseases. Unraveling the mechanisms of midbrain dopaminergic (mDA) phenotype induction and...

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Identifiers

PMID: 32503161
DOI: 10.3390/ijms21113995
PMCID: PMC7312927

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