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Article

Specification of dopaminergic subsets involves interplay of En1 and Pitx3.

Development (Cambridge, England) - 1 Aug 2013

Veenvliet Jesse V, Dos Santos Maria T M Alves, Kouwenhoven Willemieke M, von Oerthel Lars, Lim Jamie L, van der Linden Annemarie J A, Koerkamp Marian J A Groot, Holstege Frank C P, Smidt Marten P

Abstract excerpt

Mesodiencephalic dopaminergic (mdDA) neurons control locomotion and emotion and are affected in multiple psychiatric and neurodegenerative diseases, including Parkinson's disease (PD). The homeodomain transcription factor Pitx3 is pivotal in mdDA neuron development and loss of Pitx3 results in programming deficits in a rostrolateral subpopulation of mdDA neurons destined to form the substantia nigra pars compacta...

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Identifiers

PMID: 23863478
DOI: 10.1242/dev.094565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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