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Article

Regulation of release factor expression using a translational negative feedback loop: a systems analysis.

RNA (New York, N.Y.) - 1 Dec 2012

Betney Russell, de Silva Eric, Mertens Christina, Knox Yvonne, Krishnan J, Stansfield Ian

Abstract excerpt

The essential eukaryote release factor eRF1, encoded by the yeast SUP45 gene, recognizes stop codons during ribosomal translation. SUP45 nonsense alleles are, however, viable due to the establishment of feedback-regulated readthrough of the premature termination codon; reductions in full-length eRF1 promote tRNA-mediated stop codon readthrough, which, in turn, drives partial production of full-length eRF1. A...

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Share to Binding, Competitive
Share to Codon, Terminator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Genes, Fungal

Share to Peptide Termination Factors

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Source

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Identifiers

PMID: 23104998
DOI: 10.1261/rna.035113.112
PMCID: PMC3504682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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