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Article

Translational recoding as a feedback controller: systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift.

Nucleic acids research - 1 Jun 2011

Rato Claudia, Amirova Svetlana R, Bates Declan G, Stansfield Ian, Wallace Heather M

Abstract excerpt

The antizyme protein, Oaz1, regulates synthesis of the polyamines putrescine, spermidine and spermine by controlling stability of the polyamine biosynthetic enzyme, ornithine decarboxylase. Antizyme mRNA translation depends upon a polyamine-stimulated +1 ribosomal frameshift, forming a complex negative feedback system in which the translational frameshifting event may be viewed in engineering terms as a feedback...

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Identifiers

PMID: 21303766
DOI: 10.1093/nar/gkq1349
PMCID: PMC3113565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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