Article

Transcriptome-wide investigation of stop codon readthrough in <i>Saccharomyces cerevisiae</i>

2020-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide release. However, stop codon readthrough can occur when a near-cognate tRNA outcompetes eRF1 in decoding the stop codon, resulting in the continuation of the elongation phase of protein synthesis. At the end of a convent...

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Literature Corpus work: cfee8438-fb10-5ef8-aa52-a3af2689de2d
DOI: 10.1101/2020.12.15.422930

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