Article
Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast.
Nucleic acids research - 1 Sept 2010
Merritt Gloria H, Naemi Wesley R, Mugnier Pierre, Webb Helen M, Tuite Mick F, von der Haar Tobias
Abstract excerpt
Translation termination in eukaryotes typically requires the decoding of one of three stop codons UAA, UAG or UGA by the eukaryotic release factor eRF1. The molecular mechanisms that allow eRF1 to decode either A or G in the second nucleotide, but to exclude UGG as a stop codon, are currently not well understood. Several models of stop codon recognition have been developed on the basis of evidence from...
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