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Article

Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1.

Nucleic acids research - 1 Apr 2009

Hatin Isabelle, Fabret Celine, Rousset Jean-Pierre, Namy Olivier

Abstract excerpt

Translation termination in eukaryotes is completed by two interacting factors eRF1 and eRF3. In Saccharomyces cerevisiae, these proteins are encoded by the genes SUP45 and SUP35, respectively. The eRF1 protein interacts directly with the stop codon at the ribosomal A-site, whereas eRF3-a GTPase protein-probably acts as a proofreading factor, coupling stop codon recognition to polypeptide chain release. We...

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Identifiers

PMID: 19174561
DOI: 10.1093/nar/gkp012
PMCID: PMC2665212

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Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1.PMID 19174561Read ↗

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A novel mutant of the Sup35 protein of Saccharomyces cerevisiae defective in translation termination and in GTPase activity still supports cell viability.Semantic proximity Read ↗

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