Article
Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro.
Circulation research - 12 Oct 2007
Pidkovka Nataliya A, Cherepanova Olga A, Yoshida Tadashi, Alexander Matthew R, Deaton Rebecca A, Thomas James A, Leitinger Norbert, Owens Gary K
Abstract excerpt
Atherosclerosis is a vascular disease characterized by lipid deposition and inflammation within the arterial wall. Oxidized phospholipids (oxPLs), such as 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) and its constituents 1-palmytoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) are concentrated within atherosclerotic...
Topics
- Animals
- Cells, Cultured
- Kruppel-Like Factor 4
- Kruppel-Like Transcription Factors
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle
- Oxidation-Reduction
- Phenotype
- Phospholipids
- Rats