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Article

The early- and late stages in phenotypic modulation of vascular smooth muscle cells: differential roles for lysophosphatidic acid.

Biochimica et biophysica acta - 1 Sept 2008

Guo Huazhang, Makarova Natalia, Cheng Yunhui, E Shuyu, Ji Rui-Rui, Zhang Chunxiang, Farrar Patricia, Tigyi Gabor

Abstract excerpt

Lysophosphatidic acid (LPA) has been implicated as causative in phenotypic modulation (PM) of cultured vascular smooth muscle cells (VSMC) in their transition to the dedifferentiated phenotype. We evaluated the contribution of the three major LPA receptors, LPA1 and LPA2 GPCR and PPARgamma, on PM of VSMC. Expression of differentiated VSMC-specific marker genes, including smooth muscle alpha-actin, smooth muscle...

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Identifiers

PMID: 18602022
DOI: 10.1016/j.bbalip.2008.06.003
PMCID: PMC3446793

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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