Article
A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer.
Nature genetics - 1 Dec 2012
Gudmundsson Julius, Sulem Patrick, Gudbjartsson Daniel F, Masson Gisli, Agnarsson Bjarni A, Benediktsdottir Kristrun R, Sigurdsson Asgeir, Magnusson Olafur Th, Gudjonsson Sigurjon A, Magnusdottir Droplaug N, Johannsdottir Hrefna, Helgadottir Hafdis Th, Stacey Simon N, Jonasdottir Adalbjorg, Olafsdottir Stefania B, Thorleifsson Gudmar, Jonasson Jon G, Tryggvadottir Laufey, Navarrete Sebastian, Fuertes Fernando, Helfand Brian T, Hu Qiaoyan, Csiki Irma E, Mates Ioan N, Jinga Viorel, Aben Katja K H, van Oort Inge M, Vermeulen Sita H, Donovan Jenny L, Hamdy Freddy C, Ng Chi-Fai, Chiu Peter K F, Lau Kin-Mang, Ng Maggie C Y, Gulcher Jeffrey R, Kong Augustine, Catalona William J, Mayordomo Jose I, Einarsson Gudmundur V, Barkardottir Rosa B, Jonsson Eirikur, Mates Dana, Neal David E, Kiemeney Lambertus A, Thorsteinsdottir Unnur, Rafnar Thorunn, Stefansson Kari
Abstract excerpt
In Western countries, prostate cancer is the most prevalent cancer of men and one of the leading causes of cancer-related death in men. Several genome-wide association studies have yielded numerous common variants conferring risk of prostate cancer. Here, we analyzed 32.5 million variants discovered by whole-genome sequencing 1,795 Icelanders. We identified a new low-frequency variant at 8q24 associated with...
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