Article
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
Nature genetics - 1 Oct 2009
Gudmundsson Julius, Sulem Patrick, Gudbjartsson Daniel F, Blondal Thorarinn, Gylfason Arnaldur, Agnarsson Bjarni A, Benediktsdottir Kristrun R, Magnusdottir Droplaug N, Orlygsdottir Gudbjorg, Jakobsdottir Margret, Stacey Simon N, Sigurdsson Asgeir, Wahlfors Tiina, Tammela Teuvo, Breyer Joan P, McReynolds Kate M, Bradley Kevin M, Saez Berta, Godino Javier, Navarrete Sebastian, Fuertes Fernando, Murillo Laura, Polo Eduardo, Aben Katja K, van Oort Inge M, Suarez Brian K, Helfand Brian T, Kan Donghui, Zanon Carlo, Frigge Michael L, Kristjansson Kristleifur, Gulcher Jeffrey R, Einarsson Gudmundur V, Jonsson Eirikur, Catalona William J, Mayordomo Jose I, Kiemeney Lambertus A, Smith Jeffrey R, Schleutker Johanna, Barkardottir Rosa B, Kong Augustine, Thorsteinsdottir Unnur, Rafnar Thorunn, Stefansson Kari
Abstract excerpt
We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and [C] (OR =...