Article
Identification of a new prostate cancer susceptibility locus on chromosome 8q24.
Nature genetics - 1 Oct 2009
Yeager Meredith, Chatterjee Nilanjan, Ciampa Julia, Jacobs Kevin B, Gonzalez-Bosquet Jesus, Hayes Richard B, Kraft Peter, Wacholder Sholom, Orr Nick, Berndt Sonja, Yu Kai, Hutchinson Amy, Wang Zhaoming, Amundadottir Laufey, Feigelson Heather Spencer, Thun Michael J, Diver W Ryan, Albanes Demetrius, Virtamo Jarmo, Weinstein Stephanie, Schumacher Fredrick R, Cancel-Tassin Geraldine, Cussenot Olivier, Valeri Antoine, Andriole Gerald L, Crawford E David, Haiman Christopher A, Henderson Brian, Kolonel Laurence, Le Marchand Loic, Siddiq Afshan, Riboli Elio, Key Timothy J, Kaaks Rudolf, Isaacs William, Isaacs Sarah, Wiley Kathleen E, Gronberg Henrik, Wiklund Fredrik, Stattin Pär, Xu Jianfeng, Zheng S Lilly, Sun Jielin, Vatten Lars J, Hveem Kristian, Kumle Merethe, Tucker Margaret, Gerhard Daniela S, Hoover Robert N, Fraumeni Joseph F, Hunter David J, Thomas Gilles, Chanock Stephen J
Abstract excerpt
We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer...
Read the complete abstract on PubMed