Multiple regions within 8q24 independently affect risk for prostate cancer.

doi:10.1038/ng2015

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Article

Multiple regions within 8q24 independently affect risk for prostate cancer.

Nature genetics - 1 May 2007

Haiman Christopher A, Patterson Nick, Freedman Matthew L, Myers Simon R, Pike Malcolm C, Waliszewska Alicja, Neubauer Julie, Tandon Arti, Schirmer Christine, McDonald Gavin J, Greenway Steven C, Stram Daniel O, Le Marchand Loic, Kolonel Laurence N, Frasco Melissa, Wong David, Pooler Loreall C, Ardlie Kristin, Oakley-Girvan Ingrid, Whittemore Alice S, Cooney Kathleen A, John Esther M, Ingles Sue A, Altshuler David, Henderson Brian E, Reich David

Abstract excerpt

After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 x 10(-19) for the strongest association, and P <...

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Identifiers

PMID: 17401364
DOI: 10.1038/ng2015
PMCID: PMC2638766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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