Article
Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia.
Genes, brain, and behavior - 1 Mar 2009
Liao S-Y, Lin S-H, Liu C-M, Hsieh M H, Hwang T J, Liu S K, Guo S-C, Hwu H-G, Chen W J
Abstract excerpt
This study examined the relations of genetic variants in catechol-O-methyltransferase (COMT) gene, including rs737865 in intron 1, rs4680 in exon 4 (Val158Met) and downstream rs165599, to schizophrenia and its related neurocognitive functions in families of patients with schizophrenia. Totally, 680 individuals from 166 simplex (166 affected members and 354 nonpsychotic first-degree relatives) and 46 multiplex...
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