Article
Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans.
RNA (New York, N.Y.) - 1 Dec 2012
Lehrbach Nicolas J, Castro Cecilia, Murfitt Kenneth J, Abreu-Goodger Cei, Griffin Julian L, Miska Eric A
Abstract excerpt
Regulation of gene expression by microRNAs (miRNAs) is essential for normal development, but the roles of miRNAs in the physiology of adult animals are poorly understood. We have isolated a conditional allele of DGCR8/pash-1, which allows reversible and rapid inactivation of miRNA synthesis in vivo in Caenorhabditis elegans. This is a powerful new tool that allows dissection of post-developmental miRNA functions....
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