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Article

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Jan 2011

Kenyon Cynthia

Abstract excerpt

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.

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Identifiers

PMID: 21115525
DOI: 10.1098/rstb.2010.0276
PMCID: PMC3001308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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