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Article

Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans.

eLife - 20 Aug 2026

Rudich Zenith D, Guan Jiaxi, Tamez Gonzalez Aura A, Booth Grant F, Soo Sonja K, Anglas Ulrich, Mistry Meeta, Senchuk Megan M, Van Raamsdonk Jeremy M

Abstract excerpt

While aging is the greatest risk factor for the development of neurodegenerative disease, the role of aging in these diseases is poorly understood. Our previous work has shown that targeting aging pathways can be neuroprotective in animal models of neurodegenerative disease. Based on these findings, we believe that by gaining insight into the aging process that knowledge can be applied to identify novel...

Topics

Animals
Caenorhabditis elegans
Longevity
Aging
Signal Transduction
Gene Expression Regulation
Mutation
Caenorhabditis elegans Proteins
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42623273
DOI: 10.7554/eLife.112139
PMCID: PMC13493127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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