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Gene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancer

23 Oct 2012

Abstract excerpt

BACKGROUND: Toxicity from neoadjuvant chemoradiation therapy (NT) increases morbidity and limits therapeutic efficacy in patients with rectal cancer. The objective of this study was to determine whether specific polymorphisms in genes associated with rectal cancer response to NT were correlated with NT-related toxicity. METHODS: One hundred thirty-two patients with locally advanced rectal cancer received NT...

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PMID: 23096768
DOI: 10.1002/cncr.27862

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