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Article

Genetic polymorphisms in 5-Fluorouracil-related enzymes predict pathologic response after neoadjuvant chemoradiation for rectal cancer.

Surgery - 1 Nov 2016

Nelson Bailey, Carter Jane V, Eichenberger Maurice R, Netz Uri, Galandiuk Susan

Abstract excerpt

BACKGROUND: Many patients with rectal cancer undergo preoperative neoadjuvant chemoradiation, with approximately 70% exhibiting pathologic downstaging in response to treatment. Currently, there is no accurate test to predict patients who are likely to be complete responders to therapy. 5-Fluorouracil is used regularly in the neoadjuvant treatment of rectal cancer. Genetic polymorphisms affect the activity of...

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Identifiers

PMID: 27423551
DOI: 10.1016/j.surg.2016.05.017
PMCID: PMC5086288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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