Article
Potential Role of Single Nucleotide Polymorphisms of XRCC1, XRCC3, and RAD51 in Predicting Acute Toxicity in Rectal Cancer Patients Treated With Preoperative Radiochemotherapy.
American journal of clinical oncology - 1 Dec 2017
Osti Mattia F, Nicosia Luca, Agolli Linda, Gentile Giovanna, Falco Teresa, Bracci Stefano, Di Nardo Francesco, Minniti Giuseppe, De Sanctis Vitaliana, Valeriani Maurizio, Maglio Marianna, Borro Marina, Simmaco Maurizio, Enrici Riccardo M
Abstract excerpt
OBJECTIVES: To investigate the association between polymorphisms of DNA repair genes and xenobiotic with acute adverse effects in locally advanced rectal cancer patients treated with neoadjuvant radiochemotherapy. METHODS: Sixty-seven patients were analyzed for the current study. Genotypes in DNA repair genes XRCC1 (G28152A), XRCC3 (A4541G), XRCC3 (C18067T), RAD51 (G315C), and GSTP1 (A313G) were determined by...
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