Article
Pharmacogenetic study in rectal cancer patients treated with preoperative chemoradiotherapy: polymorphisms in thymidylate synthase, epidermal growth factor receptor, GSTP1, and DNA repair genes.
International journal of radiation oncology, biology, physics - 1 Dec 2011
Páez David, Salazar Juliana, Paré Laia, Pertriz Lourdes, Targarona Eduardo, del Rio Elisabeth, Barnadas Agusti, Marcuello Eugenio, Baiget Montserrat
Abstract excerpt
PURPOSE: Several studies have been performed to evaluate the usefulness of neoadjuvant treatment using oxaliplatin and fluoropyrimidines for locally advanced rectal cancer. However, preoperative biomarkers of outcome are lacking. We studied the polymorphisms in thymidylate synthase, epidermal growth factor receptor, glutathione S-transferase pi 1 (GSTP1), and several DNA repair genes to evaluate their usefulness...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.