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Article

Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer.

British journal of cancer - 22 Nov 2011

Thomas F, Motsinger-Reif A A, Hoskins J M, Dvorak A, Roy S, Alyasiri A, Myerson R J, Fleshman J W, Tan B R, McLeod H L

Abstract excerpt

BACKGROUND: There is a large degree of variation in tumour response and host toxicities associated with neoadjuvant chemoradiation for rectal cancer patients. We performed a complimentary pharmacogenetic study to investigate germline polymorphisms of genes involved in 5-fluorouracil (5-FU) and irinotecan pathways and their potential association with clinical outcomes and toxicities from neoadjuvant chemoradiation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22045187
DOI: 10.1038/bjc.2011.442
PMCID: PMC3242600

Genes

MTHFR
ABCC1
DPYD
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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