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Article

A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis.

Radiation oncology (London, England) - 27 Mar 2017

Kim Sun Young, Baek Ji Yeon, Oh Jae Hwan, Park Sung Chan, Sohn Dae Kyung, Kim Min Ju, Chang Hee Jin, Kong Sun-Young, Kim Dae Yong

Abstract excerpt

BACKGROUND: This study aimed to evaluate the efficacy of a high dose of oral tegafur-uracil (400 mg/m2) plus leucovorin with preoperative chemoradiation of locally advanced rectal cancer and to explore the impact of polymorphisms of cytochrome P 2A6 (CYP2A6), uridine monophosphate synthetase (UMPS), and ATP-binding cassette B1 (ABCB1) on clinical outcome. METHODS: Patients with cT3 or cT4 rectal cancer were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28347333
DOI: 10.1186/s13014-017-0800-5
PMCID: PMC5369180

Genes

UMPS
ABCB1

Variants

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