A Genotype Signature for Predicting Pathologic Complete Response in Locally Advanced Rectal Cancer.

doi:10.1016/j.ijrobp.2021.01.005

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Genotype Signature for Predicting Pathologic Complete Response in Locally Advanced Rectal Cancer.

International journal of radiation oncology, biology, physics - 1 Jun 2021

Xiao Wei-Wei, Li Min, Guo Zhi-Wei, Zhang Rong, Xi Shao-Yan, Zhang Xiang-Guo, Li Yong, Wu De-Qing, Ren Yu-Feng, Pang Xiao-Lin, Wan Xiang-Bo, Li Kun, Zhou Chun-Lian, Zhai Xiang-Ming, Liang Zhi-Kun, Wang Qiao-Xuan, Zeng Zhi-Fan, Zhang Hui-Zhong, Yang Xue-Xi, Wu Ying-Song, Li Ming, Gao Yuan-Hong

Abstract excerpt

PURPOSE: To construct and validate a predicting genotype signature for pathologic complete response (pCR) in locally advanced rectal cancer (PGS-LARC) after neoadjuvant chemoradiation. METHODS AND MATERIALS: Whole exome sequencing was performed in 15 LARC tissues. Mutation sites were selected according to the whole exome sequencing data and literature. Target sequencing was performed in a training cohort (n =...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Tumor-Associated, Carbohydrate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Area Under Curve

Share to Carcinoembryonic Antigen

Share to Exome Sequencing

Share to Neoadjuvant Therapy

Share to Neoplasm Staging

Share to Rectal Neoplasms

Share to Regression Analysis

Source

Open in PubMed

Identifiers

PMID: 33434612
DOI: 10.1016/j.ijrobp.2021.01.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Genotype Signature for Predicting Pathologic Complete Response in Locally Advanced Rectal Cancer.PMID 33434612Read ↗

Genetic Determinants of Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer Identified by Whole Exome Sequencing.Semantic proximity Read ↗

Genetic variations using whole-exome sequencing might predict response for neoadjuvant chemoradiotherapy in locally advanced rectal cancer.Semantic proximity Read ↗

Development of a long non-coding RNA signature for prediction of response to neoadjuvant chemoradiotherapy in locally advanced rectal adenocarcinomaSemantic proximity Read ↗

KRASG12V/A146T mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC.Semantic proximity Read ↗

Influence of KRAS mutation subtypes on response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: meta-analysis.Semantic proximity Read ↗

Exploring novel inflammation-related genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancerSemantic proximity Read ↗

Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer.Semantic proximity Read ↗

Molecular differentiation between complete and incomplete responders to neoadjuvant therapy in rectal cancerSemantic proximity Read ↗

KRAS and Combined KRAS/TP53 Mutations in Locally Advanced Rectal Cancer are Independently Associated with Decreased Response to Neoadjuvant Therapy.Semantic proximity Read ↗

Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer.Semantic proximity Read ↗

Gene-expression profiles of pretreatment biopsies predict complete response of rectal cancer patients to preoperative chemoradiotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.