Article
Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
Journal of virology - 1 Oct 2010
Leslie Alasdair, Matthews Philippa C, Listgarten Jennifer, Carlson Jonathan M, Kadie Carl, Ndung'u Thumbi, Brander Christian, Coovadia Hoosen, Walker Bruce D, Heckerman David, Goulder Philip J R
Abstract excerpt
Previous studies have identified a central role for HLA-B alleles in influencing control of HIV infection. An alternative possibility is that a small number of HLA-B alleles may have a very strong impact on HIV disease outcome, dominating the contribution of other HLA alleles. Here, we find that even following the exclusion of subjects expressing any of the HLA-B class I alleles (B*57, B*58, and B*18) identified...
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