Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Associations of functional human leucocyte antigen class I groups with HIV viral load in a heterogeneous cohort.

AIDS (London, England) - 1 Sept 2023

Zucco Adrian G, Bennedbæk Marc, Ekenberg Christina, Gabrielaite Migle, Leung Preston, Polizzotto Mark N, Kan Virginia, Murray Daniel D, Lundgren Jens D, MacPherson Cameron R

Abstract excerpt

OBJECTIVE: Human leucocyte antigen (HLA) class I alleles are the main host genetic factors involved in controlling HIV-1 viral load (VL). Nevertheless, HLA diversity has proven a significant challenge in association studies. We assessed how accounting for binding affinities of HLA class I alleles to HIV-1 peptides facilitate association testing of HLA with HIV-1 VL in a heterogeneous cohort. DESIGN: Cohort from...

Topics

Humans
Viral Load
HIV Infections
Histocompatibility Antigens Class I
HLA-B Antigens
HIV Seropositivity
HIV-1
Alleles

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 37534724
DOI: 10.1097/QAD.0000000000003557
PMCID: PMC10399941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Associations of functional human leucocyte antigen class I groups with HIV viral load in a heterogeneous cohort.PMID 37534724Read ↗

Associations of functional HLA class I groups with HIV viral load in a heterogeneous cohortSemantic proximity Read ↗

Impact of predicted HLA class I immunopeptidome on viral reservoir in a cohort of people living with HIV in Italy.Semantic proximity Read ↗

Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity.Semantic proximity Read ↗

Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy–Naive Participants From the Strategic Timing of AntiRetroviral Treatment TrialSemantic proximity Read ↗

Co-operative additive effects between HLA alleles in control of HIV-1.Semantic proximity Read ↗

Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs.Semantic proximity Read ↗

Impact of HLA class I functional divergence on HIV control.Semantic proximity Read ↗

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.Semantic proximity Read ↗

Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response.Semantic proximity Read ↗

Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen.Semantic proximity Read ↗

HIV Peptidome-Wide Association Study Reveals Patient-Specific Epitope Repertoires Associated with HIV ControlSemantic proximity Read ↗

HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV controlSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.