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Article

Conformational dynamics of the inner pore helix of voltage-gated potassium channels.

The Journal of chemical physics - 7 Jun 2009

Choe Seungho, Grabe Michael

Abstract excerpt

Voltage-gated potassium (Kv) channels control the electrical excitability of neurons and muscles. Despite this key role, how these channels open and close or gate is not fully understood. Gating is usually attributed to the bending and straightening of pore-lining helices at glycine and proline residues. In this work we focused on the role of proline in the Pro-Val-Pro (PVP) motif of the inner S6 helix in the...

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PMID: 19508102
DOI: 10.1063/1.3138906

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