Article
Intermediate state trapping of a voltage sensor.
The Journal of general physiology - 1 Dec 2012
Lacroix Jérôme J, Pless Stephan A, Maragliano Luca, Campos Fabiana V, Galpin Jason D, Ahern Christopher A, Roux Benoît, Bezanilla Francisco
Abstract excerpt
Voltage sensor domains (VSDs) regulate ion channels and enzymes by undergoing conformational changes depending on membrane electrical signals. The molecular mechanisms underlying the VSD transitions are not fully understood. Here, we show that some mutations of I241 in the S1 segment of the Shaker Kv channel positively shift the voltage dependence of the VSD movement and alter the functional coupling between VSD...
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