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Article

SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites.

Journal of neurochemistry - 1 Jan 2013

Soriano Francesc X, Chawla Sangeeta, Skehel Paul, Hardingham Giles E

Abstract excerpt

The Class IIa histone deacetylases (HDAC)4 and HDAC5 play a role in neuronal survival and behavioral adaptation in the CNS. Phosphorylation at 2/3 N-terminal sites promote their nuclear export. We investigated whether non-canonical signaling routes to Class IIa HDAC export exist because of their association with the co-repressor Silencing Mediator Of Retinoic And Thyroid Hormone Receptors (SMRT). We found that,...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23083128
DOI: 10.1111/jnc.12058
PMCID: PMC3557716

Genes

HDAC5
BDNF
HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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