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Article

Multiple novel signals mediate thyroid hormone receptor nuclear import and export.

The Journal of biological chemistry - 7 Sept 2012

Mavinakere Manohara S, Powers Jeremy M, Subramanian Kelly S, Roggero Vincent R, Allison Lizabeth A

Abstract excerpt

Thyroid hormone receptor (TR) is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. The fine balance between nuclear import and export of TR has emerged as a critical control point for modulating thyroid hormone-responsive gene expression; however, sequence motifs of TR that mediate shuttling are not fully defined. Here, we characterized multiple signals that direct TR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

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Identifiers

PMID: 22815488
DOI: 10.1074/jbc.M112.397745
PMCID: PMC3438959

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