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Article

Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.

Nature neuroscience - 1 Jul 2013

Korb Erica, Wilkinson Carol L, Delgado Ryan N, Lovero Kathryn L, Finkbeiner Steven

Abstract excerpt

The activity-regulated cytoskeletal protein Arc (also known as Arg3.1) is required for long-term memory formation and synaptic plasticity. Arc expression is robustly induced by activity, and Arc protein localizes to both active synapses and the nucleus. Whereas its synaptic function has been examined, it is not clear why or how Arc is localized to the nucleus. We found that murine Arc nuclear expression is...

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Source

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Identifiers

PMID: 23749147
DOI: 10.1038/nn.3429
PMCID: PMC3703835

Genes

PML

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