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Article

TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory.

Nature neuroscience - 1 Nov 2012

Lai Kwok-On, Wong Alan S L, Cheung Man-Chun, Xu Pei, Liang Zhuoyi, Lok Ka-Chun, Xie Hui, Palko Mary E, Yung Wing-Ho, Tessarollo Lino, Cheung Zelda H, Ip Nancy Y

Abstract excerpt

The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB participate in diverse neuronal functions, including activity-dependent synaptic plasticity that is crucial for learning and memory. On binding to BDNF, TrkB is not only autophosphorylated at tyrosine residues but also undergoes serine phosphorylation at S478 by the serine/threonine kinase cyclin-dependent kinase 5 (Cdk5). However,...

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Identifiers

PMID: 23064382
DOI: 10.1038/nn.3237
PMCID: PMC7511999

Genes

BDNF
TIAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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