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Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development

11 Nov 2015

Abstract excerpt

The proper growth and arborization of dendrites in response to sensory experience are essential for neural connectivity and information processing in the brain. Although neuronal activity is important for sculpting dendrite morphology, the underlying molecular mechanisms are not well understood. Here, we report that cyclin-dependent kinase 5 (Cdk5)-mediated transcriptional regulation is a key mechanism that...

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PMID: 26558783
DOI: 10.1523/jneurosci.1443-15.2015

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