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Article

Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.

PloS one - 1 Jan 2012

Heni Martin, Ketterer Caroline, Wagner Robert, Linder Katarzyna, Böhm Anja, Herzberg-Schäfer Silke A, Machicao Fausto, Knoch Klaus-Peter, Fritsche Andreas, Staiger Harald, Häring Hans-Ulrich, Solimena Michele

Abstract excerpt

OBJECTIVE: Polypyrimidine tract-binding protein 1 (PTBP1) promotes stability and translation of mRNAs coding for insulin secretion granule proteins and thereby plays a role in β-cells function. We studied whether common genetic variations within the PTBP1 locus influence insulin secretion, and/or proinsulin conversion. METHODS: We genotyped 1,502 healthy German subjects for four tagging single nucleotide...

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Identifiers

PMID: 23077502
DOI: 10.1371/journal.pone.0046154
PMCID: PMC3471934

Genes

PTBP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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