Article
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
Cell metabolism - 5 Jan 2011
Koeck Thomas, Olsson Anders H, Nitert Marloes Dekker, Sharoyko Vladimir V, Ladenvall Claes, Kotova Olga, Reiling Erwin, Rönn Tina, Parikh Hemang, Taneera Jalal, Eriksson Johan G, Metodiev Metodi D, Larsson Nils-Göran, Balhuizen Alexander, Luthman Holger, Stančáková Alena, Kuusisto Johanna, Laakso Markku, Poulsen Pernille, Vaag Allan, Groop Leif, Lyssenko Valeriya, Mulder Hindrik, Ling Charlotte
Abstract excerpt
Type 2 diabetes (T2D) evolves when insulin secretion fails. Insulin release from the pancreatic β cell is controlled by mitochondrial metabolism, which translates fluctuations in blood glucose into metabolic coupling signals. We identified a common variant (rs950994) in the human transcription factor B1 mitochondrial (TFB1M) gene associated with reduced insulin secretion, elevated postprandial glucose levels, and...
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