The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia.

doi:10.1210/jc.2010-0860

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Article

The impact of genetic variation in the G6PC2 gene on insulin secretion depends on glycemia.

The Journal of clinical endocrinology and metabolism - 1 Dec 2010

Heni Martin, Ketterer Caroline, Hart Leen M 't, Ranta Felicia, van Haeften Timon W, Eekhoff Elisabeth M, Dekker Jacqueline M, Boomsma Dorret I, Nijpels Giel, Kramer Mark H, Diamant Michaela, Simonis-Bik Annemarie M, Heine Robert J, de Geus Eco J, Schäfer Silke A, Machicao Fausto, Ullrich Susanne, Thamer Claus, Stefan Norbert, Staiger Harald, Häring Hans-Ulrich, Fritsche Andreas

Abstract excerpt

CONTEXT: Single-nucleotide polymorphisms (SNPs) within the G6PC2 locus are associated with fasting glucose and insulin secretion. These SNPs are not associated with type 2 diabetes risk. OBJECTIVE: Our objective was to investigate whether the impact of the SNP on variables of glucose-stimulated insulin secretion is influenced by glucose tolerance status. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTION: In this...

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PMID: 20826583
DOI: 10.1210/jc.2010-0860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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