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Article

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.

PloS one - 1 Jan 2008

Friedrich Björn, Weyrich Peter, Stancáková Alena, Wang Jianjung, Kuusisto Johanna, Laakso Markku, Sesti Giorgio, Succurro Elena, Smith Ulf, Hansen Torben, Pedersen Oluf, Machicao Fausto, Schäfer Silke, Lang Florian, Risler Teut, Ullrich Susanne, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich

Abstract excerpt

HYPOTHESIS: Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) is involved in the regulation of insulin secretion and may represent a candidate gene for the development of type 2 diabetes mellitus in humans. METHODS: Three independent European populations were analyzed for the association of SGK1 gene (SGK) variations and insulin secretion traits. The German TUEF project provided the screening population (N =...

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Identifiers

PMID: 18985156
DOI: 10.1371/journal.pone.0003506
PMCID: PMC2575233

Genes

SGK1

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